The institution is Asia's oldest in terms of student enrollment and the world's largest Catholic university with a single campus. The University of Santo Thomas has a large worldwide network of relationships and partnerships with many universities.
- Some University of Santo Thomas scholarships available for students include Santo Tomas, San Lorenzo Ruiz, Santo Domingo De Guzmán, and San Martin De Porres.
- The university has multiple research centers, with Vanda ustii, Hedyotis papa francisco i, Mycetia dagohoyana and Freycinetia nonatoi being only a few of the plant species discovered at the institution recently.